What Is Upper Airway Stimulation for Sleep Apnea?

Upper airway stimulation (UAS) is a surgical treatment for obstructive sleep apnea that works by gently stimulating the nerve that controls your tongue. Unlike CPAP, which uses a mask and air pressure to keep your airway open, UAS uses a small implant to move your tongue forward while you sleep-preventing it from blocking your throat. This device is called the Inspire system, and it’s been used in over 200,000 people worldwide since getting FDA approval in 2014.

The idea is simple: when you fall asleep, your tongue can relax and fall back, blocking your airway. That’s what causes snoring and breathing pauses. The Inspire device senses when you inhale and sends a tiny electrical pulse to the hypoglossal nerve, which moves your tongue out of the way. It turns off when you exhale, so you don’t feel it all night. No mask. No hose. No noise. Just better sleep.

Who Is a Good Candidate for This Therapy?

Not everyone with sleep apnea qualifies. UAS is meant for people who’ve tried CPAP and couldn’t stick with it. About 3 out of 10 people give up on CPAP because it’s uncomfortable, too hot, or just feels claustrophobic. If that sounds familiar, UAS might be an option.

To qualify, you need to meet a few key criteria:

  • You’re between 22 and 65 years old
  • Your body mass index (BMI) is under 35 (some centers allow up to 40)
  • Your apnea-hypopnea index (AHI) is between 15 and 100-meaning you have at least 15 breathing pauses per hour
  • Less than 25% of your apneas are central (not caused by blockage)
  • You don’t have complete collapse of the soft palate during sleep

Before you even consider surgery, you’ll need a sleep study done in the last two years and a special endoscopy test while sedated. This lets doctors see exactly where your airway collapses and whether the device will work for your anatomy.

How Does the Inspire Implant Work?

The Inspire system has three tiny parts implanted under your skin:

  1. A stimulation lead that wraps around the nerve controlling your tongue
  2. A sensing lead that detects your breathing pattern
  3. An implantable pulse generator (like a pacemaker) that sits under your collarbone

The surgery takes 2-3 hours and is done as an outpatient procedure. You’ll be under general anesthesia. There are three small incisions: one in your neck to reach the nerve, one lower down to place the breathing sensor, and one near your collarbone for the battery pack. Most people go home the same day.

After about a month of healing, your doctor turns the device on. You’ll get a small remote control-similar to a TV remote-that you use to turn the device on before bed and off when you wake up. It’s not automatic; you have to remember to use it every night. But most patients say it becomes part of their routine, like brushing their teeth.

How Effective Is It?

The numbers speak for themselves. In the main clinical trial (called the STAR trial), patients saw their breathing pauses drop by 68%. On average, AHI went from 29 events per hour down to just 9. That’s a drop from severe to mild sleep apnea for most people.

Two out of three patients had at least a 50% improvement in their symptoms. After five years, those results held steady. In real-world use, 86% of patients say it’s better than CPAP. Bed partners report no snoring or only soft snoring in 85% of cases.

One patient from Birmingham, who asked to remain anonymous, shared: “I used to wake up 10 times a night gasping for air. My wife stopped sleeping in the same room. After Inspire, I haven’t woken up once in two years. We’re back in the same bed-and I actually feel awake during the day.”

Three glowing medical implants float delicately in a surgical space, rendered in intricate anime detail with soft light trails.

What Are the Risks and Side Effects?

Like any surgery, there are risks. But serious complications are rare. Over 99% of patients don’t have major problems. The most common issues are mild:

  • Temporary tongue weakness (affects about 5% of patients, usually fades in weeks)
  • Minor pain or swelling at the incision sites
  • Small risk of infection (around 2%)
  • Need for adjustment-some people need their stimulation level tweaked once or twice after activation

Some users report a tingling sensation at first. It’s not painful, but it can feel odd. Most get used to it within 2-3 weeks. A few forget to turn the device on-especially on vacation or after a late night. That’s the biggest behavioral hurdle, not the surgery.

Unlike tonsil removal or jaw surgery, this procedure is reversible. If you decide to stop using it, the device can be removed without lasting damage to your airway.

How Does It Compare to CPAP and Other Surgeries?

CPAP is still the gold standard-but only if you can use it. Studies show 29-46% of people abandon CPAP within the first year. UAS doesn’t fix all cases, but for those who can’t tolerate CPAP, it’s the next best thing.

Compared to older surgeries like uvulopalatopharyngoplasty (UPPP), UAS is less invasive and more effective. UPPP often requires months of recovery and still fails in up to 60% of cases. UAS improves multiple areas of the airway at once-tongue, soft palate-and has a success rate over 80%.

Oral appliances are another option, but they work best for mild to moderate cases. UAS is designed for moderate to severe sleep apnea. It’s also more reliable than tongue reduction surgery, which carries higher risks of nerve damage and swallowing issues.

Cost and Insurance Coverage

The total cost of the Inspire system, including surgery and follow-up, ranges from $35,000 to $40,000. That sounds high-but think about it this way: CPAP machines cost $500-$1,000 upfront, but you’ll need to replace masks, tubing, and filters every few months. Over 5 years, that adds up to $10,000-$15,000. Plus, if CPAP fails, you’re back to square one.

Good news: insurance covers it. In the U.S., 95% of Medicare patients and 85% of private insurers now pay for UAS therapy. Most providers will help you get pre-approval. If you’re denied, you can appeal-many cases get approved on second review.

Split scene: left shows CPAP struggle with dark shadows; right shows peaceful sleep with warm glow from implant and partner beside.

What’s Next for This Technology?

The FDA expanded eligibility in 2023 to include patients with BMI up to 40 and AHI up to 100. That opened the door for many more people who were previously turned away.

Researchers are working on smaller, longer-lasting batteries and AI tools that can predict who will respond best to the device. One study in 2024 used machine learning to analyze airway scans and correctly predicted treatment success in 92% of cases.

As more doctors get trained in implantation and patient awareness grows, UAS is becoming a standard option-not just a last resort.

Real Patient Experiences

On patient forums, stories are consistent:

  • “I used to be exhausted by 2 p.m. Now I play with my kids after work without napping.”
  • “My wife says I don’t snore anymore. We’ve been sleeping in the same room for the first time in 8 years.”
  • “I thought I’d hate having something in my body. But I forgot it was even there after a few weeks.”

There are also honest reviews: “It took me a month to get used to turning it on every night. I missed a few times and felt awful the next day. Now I put the remote next to my toothbrush.”

How to Get Started

If you’ve struggled with CPAP and still feel tired, it’s time to ask your sleep doctor about UAS. Here’s your roadmap:

  1. Get a recent sleep study (within the last 2 years)
  2. Ask for a referral to a UAS center-look for hospitals with dedicated sleep surgery programs
  3. Undergo a drug-induced sleep endoscopy
  4. Meet with a surgeon and sleep specialist to review your options
  5. Check insurance coverage and get pre-approval
  6. Schedule surgery if you’re a candidate

Most centers offer free consultations. You don’t have to decide right away. Take your time. Ask questions. Bring your partner. This isn’t just about sleep-it’s about your health, your relationships, and your quality of life.

Comments (4)

Nikhil Chaurasia
  • Nikhil Chaurasia
  • November 24, 2025 AT 01:44 AM

I tried CPAP for 6 months. Felt like I was wearing a space helmet while trying to sleep. My wife started sleeping on the couch. Then I found out about Inspire. Two years later, we’re back in the same bed. No more midnight gasping. No more 3 p.m. naps. Just… peace. I didn’t think it’d work for me. But sometimes, the thing that sounds crazy is the thing that saves your life.

Miruna Alexandru
  • Miruna Alexandru
  • November 24, 2025 AT 09:58 AM

Let’s be precise: the 68% reduction in AHI is statistically significant, but the sample size in the STAR trial was n=344, with a 12% dropout rate. The long-term efficacy beyond five years remains underpowered. Furthermore, the exclusion criteria-particularly the BMI cap and central apnea threshold-introduce selection bias. This is not a panacea; it’s a niche intervention for a specific phenotype of OSA. Don’t let marketing masquerade as medicine.

Justin Daniel
  • Justin Daniel
  • November 24, 2025 AT 23:52 PM

Honestly? I was skeptical too. Thought it was sci-fi stuff. But my buddy got it done last year-same age, same BMI, same CPAP trauma. Now he’s hiking weekends, playing with his niece without falling asleep on the couch. I’m not saying it’s magic, but if you’ve been through the CPAP nightmare? It’s the closest thing to a reset button I’ve seen. Talk to your doc. No pressure. Just… maybe.

ann smith
  • ann smith
  • November 26, 2025 AT 14:26 PM

This gives me so much hope 😊 I’ve been struggling with sleep for years and CPAP felt like a prison. The idea of just turning on a little device before bed… it sounds so simple. I’m scheduling a consultation next week. Thank you for sharing this-it feels like a light at the end of a very long tunnel 🌟

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